p53-directed translational control can shape and expand the universe of p53 target genes
نویسندگان
چکیده
منابع مشابه
Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas.
The p53 pathway is critical for tumor suppression, as the majority of human cancer has a faulty p53. Here, we identified RNPC1, a p53 target and a RNA-binding protein, as a critical regulator of p53 translation. We showed that ectopic expression of RNPC1 inhibited, whereas knockdown of RNPC1 increased, p53 translation under normal and stress conditions. We also showed that RNPC1 prevented cap-b...
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The tumor suppressor protein p53 acts as a transcription factor, binding sequence-specifically to defined DNA sites, thereby activating the expression of genes leading to diverse cellular outcomes. Canonical p53 response elements (REs) are made of two decameric half-sites separated by a variable number of base pairs (spacers). Fifty percent of all validated p53 REs contain spacers between 1 and...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2014
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2014.79